Immunocytokines with target cell–restricted IL-15 activity for treatment of B cell malignancies

JOURNAL ARTICLE published 6 March 2024 in Science Translational Medicine

Authors: Latifa Zekri | Ilona Hagelstein | Melanie Märklin | Boris Klimovich | Mary Christie | Cornelia Lindner | Sofie Kämereit | Nisha Prakash | Stefanie Müller | Sophie Stotz | Andreas Maurer | Carsten Greve | Bastian Schmied | Daniel Atar | Hans-Georg Rammensee | Gundram Jung | Helmut R. Salih

Phenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic health

JOURNAL ARTICLE published 24 January 2024 in Science Translational Medicine

Authors: Seyedeh Maryam Zekavat | Saman Doroodgar Jorshery | Franziska G. Rauscher | Katrin Horn | Sayuri Sekimitsu | Satoshi Koyama | Trang T. Nguyen | Maria C. Costanzo | Dongkeun Jang | Noël P. Burtt | Andreas Kühnapfel | Yusrah Shweikh | Yixuan Ye | Vineet Raghu | Hongyu Zhao | Marzyeh Ghassemi | Tobias Elze | Ayellet V. Segrè | Janey L. Wiggs | Lucian Del Priore | Markus Scholz | Jay C. Wang | Pradeep Natarajan | Nazlee Zebardast

Disturbed gut microbiota and bile homeostasis in Giardia -infected mice contributes to metabolic dysregulation and growth impairment

JOURNAL ARTICLE published 14 October 2020 in Science Translational Medicine

Research funded by Deutsche Forschungsgemeinschaft (SPP1656 HO2236/9-2) | Deutsche Forschungsgemeinschaft (HO2236/14-1) | Deutsche Forschungsgemeinschaft (HO2236/17-1) | Deutsche Forschungsgemeinschaft (CRC1382 project A5) | Deutsche Forschungsgemeinschaft (CRC1382 project A8) | Deutsche Forschungsgemeinschaft (CRC1382 project B1) | Interdisciplinary Center for Clinical Research, Faculty of Medicine, RWTH Aachen University (Grant E8-13) | Deutsche Forschungsgemeinschaft (CRC1382 project Q1) | Deutsche Forschungsgemeinschaft (SPP1656 BL953/5-2) | Deutsche Forschungsgemeinschaft (BL953/5-2) | Deutsche Forschungsgemeinschaft (CRC900 project C2 - Projektnummer 158989968 – SFB 900) | Deutsche Forschungsgemeinschaft (CRC1371 project P13) | Deutsche Forschungsgemeinschaft (CRC1382 project Q1) | Deutsche Forschungsgemeinschaft (CRC1382 project Q1) | Interdisciplinary Center for Clinical Research, Faculty of Medicine, RWTH Aachen University (Grant E8-13) | German Centrefor Infection Research (8000 201-3) | German Center for Infection Research (8000 201-3) | Deutsche Forschungsgemeinschaft (TO1052/1-1) | German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems, Germany (8000 201-3)

Authors: Ambre Riba | Kasra Hassani | Alesia Walker | Niels van Best | Dunja von Zeschwitz | Teresa Anslinger | Nina Sillner | Stefanie Rosenhain | Daniel Eibach | Oumou Maiga-Ascofaré | Ulrike Rolle-Kampczyk | Marijana Basic | Anne Binz | Sabine Mocek | Beate Sodeik | Rudolf Bauerfeind | Antje Mohs | Christian Trautwein | Fabian Kiessling | Jürgen May | Martin Klingenspor | Felix Gremse | Philippe Schmitt-Kopplin | André Bleich | Natalia Torow | Martin von Bergen | Mathias W. Hornef

In utero exposure to maternal anti–aquaporin-4 antibodies alters brain vasculature and neural dynamics in male mouse offspring

JOURNAL ARTICLE published 20 April 2022 in Science Translational Medicine

Authors: Simone Mader | Lior Brimberg | An Vo | Joshua J. Strohl | James M. Crawford | Alexandre Bonnin | Joseph Carrión | Delcora Campbell | Tomás S. Huerta | Andrea La Bella | Roseann Berlin | Stephen L. Dewey | Matthew Hellman | David Eidelberg | Irena Dujmovic | Jelena Drulovic | Jeffrey L. Bennett | Bruce T. Volpe | Patricio T. Huerta | Betty Diamond

Wnt Proteins Promote Bone Regeneration

JOURNAL ARTICLE published 28 April 2010 in Science Translational Medicine

Authors: Steven Minear | Philipp Leucht | Jie Jiang | Bo Liu | Arial Zeng | Christophe Fuerer | Roel Nusse | Jill A. Helms

Rapid-acting antidepressant drugs modulate affective bias in rats

JOURNAL ARTICLE published 10 January 2024 in Science Translational Medicine

Authors: Justyna K. Hinchcliffe | Sarah A. Stuart | Christian M. Wood | Julia Bartlett | Katie Kamenish | Roberto Arban | Christopher W. Thomas | Aslihan Selimbeyoglu | Shaun Hurley | Bastian Hengerer | Gary Gilmour | Emma S. J. Robinson

Hormonal therapies up-regulate MANF and overcome female susceptibility to immune checkpoint inhibitor myocarditis

JOURNAL ARTICLE published 2 November 2022 in Science Translational Medicine

Authors: Yaohua Zhang | Chengcao Sun | Yajuan Li | Juan Qin | Kaushik Amancherla | Ying Jing | Qingsong Hu | Ke Liang | Zhao Zhang | Youqiong Ye | Lisa A. Huang | Tina K. Nguyen | Sergey D. Egranov | Zilong Zhao | Andrew Wu | Yutao Xi | Jun Yao | Mien-Chie Hung | George A. Calin | Jie Cheng | Bora Lim | Lorenz H. Lehmann | Joe-Elie Salem | Douglas B. Johnson | Michael A. Curran | Dihua Yu | Leng Han | Radbod Darabi | Liuqing Yang | Javid J. Moslehi | Chunru Lin

Quinolone-3-Diarylethers: A New Class of Antimalarial Drug

JOURNAL ARTICLE published 20 March 2013 in Science Translational Medicine

Authors: Aaron Nilsen | Alexis N. LaCrue | Karen L. White | Isaac P. Forquer | R. Matthew Cross | Jutta Marfurt | Michael W. Mather | Michael J. Delves | David M. Shackleford | Fabian E. Saenz | Joanne M. Morrisey | Jessica Steuten | Tina Mutka | Yuexin Li | Grennady Wirjanata | Eileen Ryan | Sandra Duffy | Jane Xu Kelly | Boni F. Sebayang | Anne-Marie Zeeman | Rintis Noviyanti | Robert E. Sinden | Clemens H. M. Kocken | Ric N. Price | Vicky M. Avery | Iñigo Angulo-Barturen | María Belén Jiménez-Díaz | Santiago Ferrer | Esperanza Herreros | Laura M. Sanz | Francisco-Javier Gamo | Ian Bathurst | Jeremy N. Burrows | Peter Siegl | R. Kiplin Guy | Rolf W. Winter | Akhil B. Vaidya | Susan A. Charman | Dennis E. Kyle | Roman Manetsch | Michael K. Riscoe

Fatty Acid Oxidation and Malonyl-CoA Decarboxylase in the Vascular Remodeling of Pulmonary Hypertension

JOURNAL ARTICLE published 11 August 2010 in Science Translational Medicine

Authors: Gopinath Sutendra | Sebastien Bonnet | Gael Rochefort | Alois Haromy | Karalyn D. Folmes | Gary D. Lopaschuk | Jason R. B. Dyck | Evangelos D. Michelakis

Depicting brighter possibilities for treating blindness

JOURNAL ARTICLE published 29 May 2019 in Science Translational Medicine

Authors: José-Alain Sahel | Jean Bennett | Botond Roska

Wastewater surveillance facilitates climate change–resilient pathogen monitoring

JOURNAL ARTICLE published 18 October 2023 in Science Translational Medicine

Authors: Megan B. Diamond | Elizabeth Yee | Manisha Bhinge | Samuel V. Scarpino

Heterogeneous antiretroviral drug distribution and HIV/SHIV detection in the gut of three species

JOURNAL ARTICLE published 3 July 2019 in Science Translational Medicine

Research funded by National Institutes of Health (R01 AI111891) | National Institutes of Health (P51 OD011107) | National Institutes of Health (K23 DK113225) | National Institutes of Health (AI111899) | National Institutes of Health (AI073146) | National Cancer Institute (HHSN261200800001E)

Authors: Corbin G. Thompson | Elias P. Rosen | Heather M. A. Prince | Nicole White | Craig Sykes | Gabriela de la Cruz | Michelle Mathews | Claire Deleage | Jacob D. Estes | Paige Charlins | Leila R. Mulder | Martina Kovarova | Lourdes Adamson | Shifali Arora | Evan S. Dellon | Anne F. Peery | Nicholas J. Shaheen | Cynthia Gay | David C. Muddiman | Ramesh Akkina | J. Victor Garcia | Paul Luciw | Angela D. M. Kashuba

Fundamental science behind today’s important medicines

JOURNAL ARTICLE published 25 April 2018 in Science Translational Medicine

Authors: Jonathan M. Spector | Rosemary S. Harrison | Mark C. Fishman

Multispecies transcriptomics identifies SIKE as a MAPK repressor that prevents NASH progression

JOURNAL ARTICLE published 14 February 2024 in Science Translational Medicine

Authors: Lan Bai | Weiyi Qu | Xu Cheng | Hailong Yang | Yong-Ping Huang | Zhenya Wang | Cuijuan Han | Rui-Feng Tian | Fengjiao Hu | Ling Yang | Song Tian | Han Tian | Zhiwei Cai | Juan Wan | Jingwei Jiang | Jiajun Fu | Junjie Zhou | Yufeng Hu | Tengfei Ma | Xin Zhang | Yan-Xiao Ji | Jingjing Cai | Zhi-Gang She | Yibin Wang | Peng Zhang | Lingli Huang | Hongliang Li | Xiao-Jing Zhang

Autologous transplantation of P63 ⁺ lung progenitor cells for chronic obstructive pulmonary disease therapy

JOURNAL ARTICLE published 14 February 2024 in Science Translational Medicine

Authors: Yujia Wang | Zili Meng | Ming Liu | Yueqing Zhou | Difei Chen | Yu Zhao | Ting Zhang | Nanshan Zhong | Xiaotian Dai | Shiyue Li | Wei Zuo

Na _v 1.7 target modulation and efficacy can be measured in nonhuman primate assays

JOURNAL ARTICLE published 19 May 2021 in Science Translational Medicine

Authors: Richard L. Kraus | Fuqiang Zhao | Parul S. Pall | Dan Zhou | Joshua D. Vardigan | Andrew Danziger | Yuxing Li | Christopher Daley | Jeanine E. Ballard | Michelle K. Clements | Rebecca M. Klein | Marie A. Holahan | Thomas J. Greshock | Ronald M. Kim | Mark E. Layton | Christopher S. Burgey | Jordi Serra | Darrell A. Henze | Andrea K. Houghton

Mapping the Road Forward in Alzheimer’s Disease

JOURNAL ARTICLE published 21 December 2011 in Science Translational Medicine

Authors: David M. Holtzman | Alison Goate | Jeffrey Kelly | Reisa Sperling

Development of Newborn and Infant Vaccines

JOURNAL ARTICLE published 6 July 2011 in Science Translational Medicine

Authors: Guzman Sanchez-Schmitz | Ofer Levy

Inhibition of RIP1 improves immune reconstitution and reduces GVHD mortality while preserving graft-versus-leukemia effects

JOURNAL ARTICLE published 20 December 2023 in Science Translational Medicine

Authors: Mariano Prado-Acosta | Seihwan Jeong | Alberto Utrero-Rico | Tatiana Goncharov | Joshua D. Webster | Ernst Holler | George Morales | Sergio Dellepiane | John E. Levine | Michael E. Rothenberg | Domagoj Vucic | James L. M. Ferrara

CD23 ⁺ IgG1 ⁺ memory B cells are poised to switch to pathogenic IgE production in food allergy

JOURNAL ARTICLE published 7 February 2024 in Science Translational Medicine

Authors: Miyo Ota | Kenneth B. Hoehn | Weslley Fernandes-Braga | Takayuki Ota | Carlos J. Aranda | Sara Friedman | Mariana G. C. Miranda-Waldetario | Jamie Redes | Maria Suprun | Galina Grishina | Hugh A. Sampson | Alefiyah Malbari | Steven H. Kleinstein | Scott H. Sicherer | Maria A. Curotto de Lafaille